That's a great question Serena. Often we think about things to do without paying attention to what we should not be doing at all.
I suggest digging deeper into your emotions, behaviors and actions to identify what's leading to overwhelm - do you have a tendency to be too hard on yourself, are you constantly trying to meet others expectations or simply working round the clock is contributing to it?
Once you have some understanding of the root cause, identify which behaviors add value to your work and which behaviors only bring stress and anxiety.
Stop doing inconsequential activities.
Stop doing extra work (say no).
Stop being a perfectionist (if you have that problem).
Start doing more impactful work.
Start looking for better opportunities.
Start finding new ways to contribute than just the assigned tasks.
I can write a complete post on it, but I hope some initial thoughts would help.